Integrated Systems and High Throughput Screening
THz-Raman™ spectroscopy extends the power of traditional Raman into the terahertz/low-frequency domain, revealing crystal structures, polymorphs, and intermolecular interactions that conventional Raman cannot. Our industry-leading patented approaches combine ultra-narrowband notch and ASE clean-up filters, built-in thermal compensation, and flexible sample accessories to deliver stable, real-time performance without special sample preparation.
From in situ probes for in line monitoring of manufacturing processes to fully integrated platforms with spectrometers and custom software, we offer complete solutions tailored to your needs. For pharmaceutical applications, our Waldo™ THz-Raman platform provides automated wellplate-based measurements designed to achieve low limits of detection, along with spatial mapping and crystallinity analysis. This accelerates drug development and quality control by enabling high-throughput, reliable data collection. With a full range of components, modules, and turnkey systems, we make even the most complex low frequency THz-Raman measurements accessible, reliable, and cost-effective.
Applications
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Polymorph Detection and Identification
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Salt Screening
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Protein Crystallization
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Formulation Stability-hydration, co-crystals and excipient interactions
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Patent/IP enhancement
WPS: High-Throughput Screening System
The WPS combines Ondax’s patented low-frequency/THz-Raman™ technology and High Throughput screening, enabling rapid screening and identification of Active Pharmaceutical Ingredient (API) polymorphs. By probing low-frequency vibrational modes associated with crystal lattice structure, THz-Raman™ provides fast, sensitive, and reliable measurement of both chemical composition and molecular structure. With simple sample handling and automated measurement, WPS streamlines the screening workflow, allowing researchers to spend more time analyzing results and less time collecting data.
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WALDO: Versatile HTS System
WALDO builds on the WPS high-throughput THz-Raman™ screening platform by adding flexible measurement geometries for a wider range of microplate formats. WALDO supports laser scanning through transparent well plates as well as top-down excitation for opaque plates, including stainless steel and Kapton plates commonly used for PXRD experiments.
This dual-mode capability allows researchers to perform rapid polymorph screening and crystallinity analysis across different sample holders while leveraging the sensitivity of low-frequency THz-Raman™ spectroscopy to probe crystal lattice structure and molecular composition.
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WALDO-SHIM: Advanced HTS System (Coming Fall 2026)
WALDO SHIM integrates Second Harmonic Imaging Microscopy (SHIM) with THz-Raman™ high-throughput screening platforms to enable rapid detection and characterization of crystalline materials during automated screening workflows. THz-Raman™ is selective but not sensitive to detect very small crystals (<10um). SHIM is a nonlinear optical imaging technique that used a ultrafast femtosecond laser to selectively detect non-centrosymmetric crystalline structures, allowing the visualization of early-stage crystals and <10um crystallites that are often invisible to conventional bright-field imaging. SHIM is a sensitive method but not selective. By combining SHIM imaging with Raman spectroscopy, WALDO SHIM provides both early crystal detection and molecular identification within the same screening system. The SHIM module identifies the presence and location of nascent crystals across high-density microplate wells, while THz-Raman™ analysis confirms chemical composition and polymorphic form.
ORCA: Crystallinity Analyzer (Coming Summer 2026)
ORCA is a THz-Raman™ crystallinity meter that uses a scanning laser beam to detect and identify low concentrations of specific polymorphs of Active Pharmaceutical Ingredients (APIs) within complex mixtures. By probing low-frequency lattice vibrations that are highly sensitive to crystal structure, ORCA enables reliable detection of targeted polymorphic forms even at very low concentrations.
This rapid, non-destructive technique requires little to no sample preparation and provides a powerful complement to PXRD for solid-form characterization. ORCA supports polymorph screening, crystallinity analysis, and pharmaceutical quality control, enabling fast identification of crystalline phases directly within heterogeneous samples.